Boss Stem Cells (2024)

Boss Stem Cells (or simply Boss Cells) are permanent items that increase the difficulty of the game when active. The first one is acquired by beating the Hand of the King, the Queen TQatS, or Dracula - Final FormRtC with no Boss Stem Cells active, the second by beating either with one active, and so on. However, the fifth Boss Stem Cell is obtained by beating the GiantRotG with four active. The use of Aspects prevents the acquirement of the next Boss Stem Cell.

Boss Stem Cells can be injected and removed at the start of the game in the Tube, as long as one hasn't left the starting area. Each one makes the game significantly harder by increasing enemy tier, density, variety, and limiting healing options. On the other hand, higher difficulty levels also increase cells dropped from enemies and the level of the Legendary Forge, and allow access to new blueprints and bonus doors scattered through the levels, as well as some that are dropped by enemies exclusive to high BSCs. The bonus doors show the number of Boss Stem Cells required to enter and will shine blue if enough are currently active.

Contents

  • 1 Modifiers
  • 2 Trivia
  • 3 History
  • 4 Gallery

Modifiers[edit]

# of Boss Stem CellsModifiers

Boss Stem Cells (1)

  • Boss Stem Cells (2) Hard difficulty
  • The early phases of bosses change.
  • Boss Stem Cells (3) Health Fountains are only available at every other Passage, those without them will instead contain a Flask recharge.
  • Boss Stem Cells (4) Improves the cap of the Legendary Forge, allowing you to upgrade the frequency of ++ items to 100%.
  • Unlocks a door in Prison Depths that leads to the Ancient Sewers.
  • Unlocks a door in Corrupted Prison that leads to the Ramparts.
  • Allows you to collect the 2nd Boss Stem Cell.

Boss Stem Cells (5)

  • Boss Stem Cells (6) Very Hard difficulty
  • The early phases of bosses change.
  • Boss Stem Cells (7) Removes all Health Fountains from Passages, but they will still contain one Flask charge each.
  • Boss Stem Cells (8) Improves the cap of the Legendary Forge, allowing you to upgrade the frequency of S items to 25%.
  • Boss Stem Cells (9) Multiplies the amount of cells dropped by enemies by 2.
  • Unlocks a door in Slumbering Sanctuary that leads to the CavernRotG.
  • Unlocks a door in Forgotten Sepulcher that leads to Guardian's HavenRotG.
  • Allows you to collect the 3rd Boss Stem Cell.

Boss Stem Cells (10)

  • Boss Stem Cells (11) Expert difficulty
  • The early phases of bosses change.
  • Boss Stem Cells (12) Passages now only contain 3 Flask charges in total, the 1st one after the first boss, the 2nd one before the second boss and the 3rd one after the LighthouseTQatS.
  • Boss Stem Cells (13) Improves the cap of the Legendary Forge, allowing you to upgrade the frequency of S items to 50%.
  • Boss Stem Cells (14) Multiplies the amount of cells dropped by enemies by 2.
  • Boss Stem Cells (15) Allows you to collect Scroll Fragments.
  • Increases item levels by +1.
  • Boss Stem Cells (16) Colorless items from Cursed Chests are improved from ++ to S-quality.
  • Unlocks a door in Ramparts that leads to the Insufferable Crypt.
  • Allows you to collect the 4th Boss Stem Cell.

Boss Stem Cells (17)

  • Boss Stem Cells (18) Nightmare difficulty
  • The early phases of bosses change.
  • Increases the detection range of mobs and gives most of them the ability to teleport to you.
  • Boss Stem Cells (19) Passages don't contain any Flask charges.
  • Boss Stem Cells (20) Improves the cap of the Legendary Forge, allowing you to upgrade the frequency of S items to 100%.
  • Boss Stem Cells (21) Multiplies the amount of cells dropped by enemies by 3.
  • Boss Stem Cells (22) Allows you to collect more Scroll Fragments than on the Expert Difficulty.
  • Increases item levels by +3.
  • Boss Stem Cells (23) Colorless items from Cursed Chests are improved from ++ to S-quality.
  • Allows you to collect the 5th Boss Stem Cell from the GiantRotG.

Boss Stem Cells (24)

  • Boss Stem Cells (25) Hell difficulty
  • The early phases of bosses change.
  • Increases the detection range of mobs and gives most of them the ability to teleport to you.
  • Boss Stem Cells (26) The Malaise is activated.
  • Boss Stem Cells (27) Passages don't contain any Flask charges.
  • Boss Stem Cells (28) Improves the cap of the Legendary Forge, allowing you to upgrade the frequency of S items to 100%.
  • Boss Stem Cells (29) Multiplies the amount of cells dropped by enemies by 3.
  • Boss Stem Cells (30) Allows you to collect more Scroll Fragments than on the Expert Difficulty.
  • Increases item levels by +3.
  • Boss Stem Cells (31) Colorless items from Cursed Chests are improved from ++ to S-quality
  • Gives access to the seventh stage,RotG which is located at the end of Throne Room.
  • The Collector's Intern replaces the Collector in Passages.

Trivia[edit]

  • When Boss Stem Cells, then named Boss Runes, were added in the v0.5.3 patch of the Foundry Update, they could all be obtained on 0 BSC difficulty and each was dropped by a different boss.

History[edit]

  • 0.5: Introduced.
  • 1.2: Introduced 5 BSC difficulty.
  • 1.9: Removed legendary item improvements from 3+ BSC that added one stat of each color.
  • 2.3: Adjusted BSC difficulty curve:
    • 2 BSC now grants a flask recharge in every Passage.
    • 3 BSC now grants a flask recharge after the first boss, before the second boss and after the Lighthouse.
    • 4 BSC no longer has the Malaise mechanic.
  • 3.0: The Hunter's Grenade no longer provides stats.

Gallery[edit]

Navigation wiki
Boss Stem Cells (38)Biomes (map) • Boss Stem Cells (39)EnemiesBoss Stem Cells (40)BossesBoss Stem Cells (41)GearBoss Stem Cells (42)MutationsBoss Stem Cells (43)Runes and upgradesBoss Stem Cells (44)OutfitsBoss Stem Cells (45)AspectsBoss Stem Cells (46)Custom ModeBoss Stem Cells (47)Boss RushBoss Stem Cells (48)Daily ChallengeBoss Stem Cells (49)StatsBoss Stem Cells (50)Boss Stem CellsBoss Stem Cells (51)MalaiseBoss Stem Cells (52)CurseBoss Stem Cells (53)Challenge RiftsBoss Stem Cells (54)ShopsBoss Stem Cells (55)CurrencyBoss Stem Cells (56)AffixesBoss Stem Cells (57)Status effectsBoss Stem Cells (58) MechanicsBoss Stem Cells (59)HazardsBoss Stem Cells (60)ObjectsBoss Stem Cells (61)PickupsBoss Stem Cells (62)NPCsBoss Stem Cells (63)LoreBoss Stem Cells (64)AchievementsBoss Stem Cells (65)SoundtracksBoss Stem Cells (66)ControlsBoss Stem Cells (67)Version historyAll DLC
Boss Stem Cells (2024)

FAQs

What do boss stem cells do? ›

Boss Stem Cells can be injected and removed at the start of the game in the Tube, as long as one hasn't left the starting area. Each one makes the game significantly harder by increasing enemy tier, density, variety, and limiting healing options.

How do you activate boss stem cells? ›

As you proceed to the right, you'll see a large glass tube that you can interact with. In this tube, you can activate the obtained boss stem cells for higher difficulties, which we will do now. By activating the first boss stem cell, you'll see in a window the changes that occur in that run.

Why are stem cells banned in the US? ›

Opponents argue that the research is unethical, because deriving the stem cells destroys the blastocyst, an unimplanted human embryo at the sixth to eighth day of development. As Bush declared when he vetoed last year's stem cell bill, the federal government should not support “the taking of innocent human life.”

Where does Tony Robbins go for stem cells? ›

Stem Cell Institute in Panama

To receive his treatment, Robbins traveled to our treatment facility in Panama City, Panama. We treat patients similar to Robbins every single day— those who are suffering from chronic illnesses or injuries and haven't found success elsewhere by administering Advanced Stem Cell Therapy.

How successful are stem cells? ›

Stem Cell Success Rates

For example, in treating certain types of blood cancers, stem cell transplants have a success rate of 60-70%. In regenerative medicine, stem cell therapy for joint repair. autoimmune or inflammatory conditions have reported success rates of around 80%.

Is it worth keeping stem cells? ›

These cells have the amazing ability to grow into many different kinds of cells, like bone marrow cells, blood cells, or brain cells. This can make them valuable for treating some diseases. Diseases that can be treated with stem cell transplants include leukemia, Hodgkin's disease, and some types of anemia.

How long does it take for stem cells to start working? ›

How long does it take to work? Some patients begin to feel relief and notice the effects of stem cell injections in as little as 2 weeks. However, most cases take about 6-12 weeks to experience full comfort and progress in healing. Different factors will affect the efficacy of MSC therapy.

What vitamins activate stem cells? ›

If you ask what supplements increase stem cells, these include vitamin D3 and C, Curcumin, Glucosamine, Chondroitin, Resveratrol and Fish Oil.
  • Vitamin C and D. Vitamin C aids our bone marrow stem cells by promoting their production (upsurge in numbers). ...
  • Curcumin. ...
  • Glucosamine and Chondroitin. ...
  • Resveratrol.

How do you activate stem cells naturally? ›

The most natural stem activators are seafood and fatty fish. Loaded with omega-3 fats, these fish help in reducing inflammation, boost the immune system, and lower the risk of heart disease. If you're a vegetarian, or do not enjoy seafood, your doctor may prescribe fish oil capsules to increase stem cell production.

What can stem cells cure? ›

Stem cell transplants are most often used to treat people with cancers that affect blood cells, such as leukemia, lymphoma, multiple myeloma, and myelodysplastic syndromes. They may also be used for neuroblastoma, Ewing sarcoma, brain tumors that have come back in children, germ cell tumors, and testicular cancer.

What are the disadvantages of stem cells? ›

Mutations have been observed in stem cells cultured for a number of generations, and some mutated stem cells have been observed to behave like cancer cells. Cultured stem cells could be contaminated with viruses which would be transferred to a patient.

Where is the best place for stem cell therapy in the US? ›

The Mayo Clinic:

With a reputation that precedes it, the Mayo Clinic is a world-renowned medical institution. Its Regenerative Medicine program focuses on replacing damaged tissues and organs by harnessing the body's innate healing mechanisms, chiefly through stem cell therapies.

Did Tiger Woods use stem cells? ›

Tiger Woods | Professional Golfer

The famous golfer confirmed in 2010 that he had undergone a stem cell treatment.

Where did Joe Rogan go for stem cell therapy? ›

Joe Rogan Praises Stem Cell Therapy In Panama With Peter Berg - Stem Cell Institute Panama.

Where did Mel Gibson get stem cells? ›

After speaking with Neil Riordan, PA, PhD, a family friend, who is a former doctor at the Mayo Clinic, put the Gibsons in touch with Stem Cell Institute Panama. Mel talked to Dr. Riordan, our chairman and founder, and Dr. Jorge Paz-Rodriguez, our medical director, over the phone.

What is the main purpose of stem cells? ›

Stem cells are the only cells in your body that make different cell types, like blood, bone and muscle cells. They also repair damaged tissue. Now, stem cells are essential blood cancer and blood disorder treatments. Medical researchers believe stem cells also have the potential to treat many other diseases.

Why do bodybuilders take stem cells? ›

IGF-1, Muscle Growth and Recovery

IGF-1 increases muscle hypertrophy, muscle mass and strength, and reduces muscle degeneration by increasing satellite cells. Satellite cells are also known as adult muscle stem cells. They promote muscle growth and repair upon injury.

What are the rewards for boss cells? ›

Rewards for beating a boss is gold, random items and on higher Boss Stem Cells scroll fragments. Beating a boss without getting hit rewards a random Legendary item.

What do stem cells do to the brain? ›

Stem cells are part of the body's repair system. They have the potential to replace specialized cells—such as muscle cells, blood cells, and brain cells—that have been damaged by injury or disease. The amount of repair that stem cells do in the adult body is limited.

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